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__**General information:**__
toc Phenylketonuria is an autosomal recessive genetic disorder. A mutation in the enzyme phenylalanine hydroxylase(PAH) renders it non-functional. The enzyme is required to metabolize the amino acid phenylalanine(Phe) to the amino acid tyrosine. When PAH is mutated and no longer operating effectively phenylalanine accumulates and is converted into phenylpyruvate. Phenylketonuria today is much more easily treatable then it was in the past. Now all newborns in developed countries around the world are screened for several genetic disorders and diseases. If PKU is not discovered early on, and the child is not raised with medication or a special diet, they will suffer from progressive mental retardation, seizures, and ultimately brain damage and in less extreme cases at best will result in ADHD. This is due to large dosages of phenylpyruvate in the body that buildup after a shot time and through a mechanism not well understood it is toxic to the centeral nervious system and poisons the brain. There is no true cure for PKU, but there is hope. Several treatments (with varying success) do exist, and a child with PKU is capable of leading a perfectly happy and healthy life.

__**History:**__
Phenylketonuria was discovered by the Norwegian physician Ivar Asbjørn Følling in 1934 when he observed that hyperphenylalaninemia (HPA ) was associated to mental retardation. In Norway, the disease is called “the Folling disease” according to him. Dr. Folling was among the first physicians to study disease by a careful chemical analysis. Having analyzed the urine of two mentally disabled children (ages 4 and 7) he asked a large number of physicians near Oslo to test the urine of other retarded patients. This led to discover the same substance that he had found in eight other patients. His tests showed him that the reactions gave rise to benzaldehyde and benzoic acid, which has led to the conclusion that this compound contained a benzene ring. Folling found that these samples contained neither protein or glucose. To test these samples he used Ferric Chloride, a chemical normally used to find ketones in diabetics. If ketones are present, a urine sample will turn purple or burgundy where with regular urine it would turn brown. However these samples became green. This indicated the presence of an unknown chemical in their systems. Using chemical analysis he found that it's molecular formula had nine carbon atoms, eight hydrogen atoms and three oxygen atoms. This showed the material to be acidic and stronger oxidation made it oxalic acid which could be precipitated by benzoic acid and calcium. This was detected through distillation.

Additional tests showed that the melting point was the same as phenylpyruvic acid , which indicated that it was the substance found in urine. Folling's additional contributions to learning about the disease involve suggestions to manage it via diet and proposing the idea that it was inherited. It is from 1953 that Horst Bickel offers a treatment by diet. Bickel suggested to limit phenylalanine in the diet to a certain amount to bring its level in the blood at a normal rate. He showed that by making this restriction until 21 days, it was extremely effective in the following days. The first test has been done on Sheila Jones whose mental capacity and general condition improved. Since the early 60's, Robert Guthrie developed a systematic screening for PKU in now borns. The Guthrie test was the first test to start and would kick off the diet that would help people with PKU avoid irreversible mental deterioration. Children who maintain phenylalanine levels in the standards permitted through out heir lives will have a normal neurological development.

**__Genes:__**
In defining the odds, Phenylketonuria is an autosomal recessive gene. If it is to be passed on it requires that both parties are at least “carriers” of the gene. If so there is a 25% chance that each pregnancy the baby will inherit PKU. Carriers in the general populace are 1 in 50 and the chances that both will meet and conceive a child is 1 in 2500, in the United States 1 in 10,000 to 15,000 newborns are born with PKU. The PAH gene carries instruction for the creation of the enzyme phenylalanine hydroxylase which converts the amino acid phenylalanine to other major compounds in the body.When mutations reduce the activity of phenylalanine hydroxylase, phenylalanine from the diet cannot effectively be processed.

In an effort to prevent or inform, carrier tests are provided through PKU treatment programs to identify if either potential parent is a carrier.



__**Diagnosis:**__
As previously noted diagnosis takes place shortly after birth by a small blood sample. In the past the diagnosis was made ​​by recognizing symptoms, and the presence of alternative products of metabolism in the urine. Today, the screening test can identify the disease early on. After the child has been fed as early as 24 hours before (but preferably 48 hours) it's blood is taken. During the blood sample the baby’s heel is cleansed with alcohol and pricked with a needle for blood. The blood is put on a piece of special paper. If the test is positive more tests will be done to confirm. If the baby is older than 6 weeks then a urine test will be done. This is accomplished by placing a drop of special fluid or a special test strip on a diaper with fresh urine on it. Levels of phenylalanine vary from one person to another. People who are considered to be “normal” have less than 3 mg/dl (milligrams per deciliter) of phenylalanine in their blood. Rising up the chain we’ll start with people who have MHP (hyperphenylalaninemia) which is described as “variant” PKU. For them phenylalanine levels range from 3- 10 mg/dl, Mild PKU ranges from 10-15 and moderate PKU ranges from 15-20. Lastly those with “classic” PKU are the ones who have it the worst. Their phenylalanine levels range from anything greater than 20 mg/dl in their blood.

Before starting a diet, there is needed at first a load test of tetrahydrobiopterin, a urine check of biopterin and neopterin as well as a definition of the activity of the enzyme dihydropteridine reductase ( DHPR) in the red blood cells ( erythrocytes) to exclude an atypical phenylketonuria. Moreover, p renatal diagnosis which is an examination of the amniotic fluid(amniocentesis ) allows during the pregnancy to see in mothers with phenylketonuria if the child is also a bearer of this metabolic defect.

There for the child has a 50% risk of contracting the disease from the phenotype, since the child will automatically receive the default of his mother, and a 50 % from the heterozygous father.

__**Treatment/Diet:**__
The affected child can live with a normal brain development by following a diet low in phenylalanine.The goal is to obtain a blood concentration of phenylalanine between 2 and 5mg/100ml below the age of 8. In pregnant women with the disease, the rate must not exceed the 2mg/100ml before and during pregnancy to avoid any anomaly for the baby.

Because people with PKU lack the enzyme to break down the amino acid, phenylalanine, they reframe from eating foods with protein, as they have phenylalanine in them as well. This includes foods like milk, cheese, fish, yogurt, chicken, eggs, bread, normal pasta and etc. Instead they eat a strict diet of fruits and vegetables and some have made special pastas to eat as well. Other options include, a synthetic formula used as a nutritional substitute and flavored bars and pills. This along with the drug "Kuvan" constitutes the treatment for PKU.

A Drug called “Kuvan” produced by Biomarin Pharmaceutical Inc. can be used to increase enzyme activity which in turn lowers phenylalanine levels. It however cannot be used by women with PKU who are pregnant and as equally important it does not work for everyone. Success has been more consistent with those with mild hyperphenylalaninemia or “variant” PKU. However it is encouraged that the drug be tested for some time to find out if the drug will work, as there is no way of knowing beforehand. If it is successful in lowering phenylalanine levels then a consultation with a doctor is required to determine the dosages to be taken. In some rare cases people who take the drug are able to quit the diet entirely but typically the result is a greater tolerance for dietary phenylalanine giving way for a more lenient diet.

__**Sources:**__
1. (Benjamin W. Van Voorhees, David Zieve ([]) 2. Fox News ([]),  3. Keith F. Widaman ([])  4. VirginiaE. Schuett ([])  5. WebMD ([])  6. ([])  7. ([])  8. ([])  9. ([])  10.([])  11.([]) 12.([]) 13. www.pku.com 14. http://www.pkuworldlink.org/history.html 15. Prof Harvey L Levy MD http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2960961-0/abstract 16. Hoeksma M, Reijngoud DJ http://www.ncbi.nlm.nih.gov/pubmed/19201235

Folling's additional contributions to learning about the disease involve suggestions to manage it via diet and proposing the idea that it was inherited. It is from 1953 that Horst Bickel offers a treatment by diet. Bickel suggested to limit phenylalanine in the diet to a certain amount to bring its level in the blood at a normal rate. He showed that by making this restriction until 21 days, it was extremely effective in the following days: the mental capacity and general condition of patients improved. Since the early 60's, Robert Guthrie developed a systematic screening for PKU in new borns. The Guthrie test, thus starting the diet in the first days of life and avoid irreversible mental deterioration. Children who maintain phenylalanine levels in the standards permitted through out their lives will have a normal neurological development. 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]